Having escaped years of imprisonment, vampire warrioress Selene finds herself in a changed world where humans have discovered the existence of both Vampire and Lycan clans and are conducting an all-out war to eradicate both immortal species. Now Selene must battle the humans and a frightening new breed of super Lycans to ensure the death dealers' survival.
88 min.
Måns Mårlind / Björn Stein
| Kate Beckinsale | Selene |
| Stephen Rea | Dr. Jacob Lane |
| Michael Ealy | Detective Sebastian |
| Theo James | David |
| India Eisley | Eve |
| Charles Dance | Thomas |
| Sandrine Holt | Lida |
| Sanny van Heteren | BBC Announcer (uncredited) |
| Jacob Blair | Kolb (Officer) |
| Robert Lawrenson | Waterfront Cop |
| Kurt Max Runte | Leader of the Troop |
| Marvin Duerkholz | Lestroy |
| Ron Wear | Jack Fletcher |
| Richard Cetrone | Lycan 1 |
| Dan Payne | Lycan 2 |
| Mark Gibbon | Announcing Guard |
| Benita Ha | Surgical Nurse |
| Tyler McClendon | Scientist |
| Panou | Old City Cop #1 |
| Ian Rozylo | Old City Cop #2 |
| Kristen Holden-Ried | Quint Lane |
| John Innes | Medical Supervisor |
| Lee Majdoub | Desk Guard |
| Catlin Adams | Olivia |
| Adam Greydon Reid | Med Tech |
| Christian Tessier | Security Guard #1 |
| Wes Bentley | Antigen Scientist (uncredited) |
| Scott Speedman | Michael (archive footage) (uncredited) |
| Joe Censoplano | Cadillac Driver (uncredited) |
| Preston Cook | Antigen Surgeon (uncredited) |